{"id":5965,"date":"2025-08-14T19:46:09","date_gmt":"2025-08-14T11:46:09","guid":{"rendered":"https:\/\/www.editage.cn\/sci-writing\/?p=5965"},"modified":"2025-09-14T12:53:53","modified_gmt":"2025-09-14T04:53:53","slug":"%e5%8c%bb%e5%ad%a6%e6%9c%af%e8%af%ad%e7%9a%84%e7%94%9f%e6%ad%bb%e5%8a%ab%ef%bc%9a%e4%b8%80%e7%af%87%e8%a2%ab%e6%8b%92%e7%a8%bf%e7%9a%84%e5%90%af%e7%a4%ba","status":"publish","type":"post","link":"https:\/\/www.editage.cn\/sci-writing\/5965\/","title":{"rendered":"\u533b\u5b66\u672f\u8bed\u7684\u201c\u751f\u6b7b\u52ab\u201d\uff1a\u4e00\u7bc7\u88ab\u62d2\u7a3f\u7684\u542f\u793a"},"content":{"rendered":"

\"\u8bba\u6587\u6da6\u8272\n\"<\/p>\n

\u5f53\u300a\u67f3\u53f6\u5200\u300b\u5ba1\u7a3f\u610f\u89c1\u6307\u51fa\u201c\u6df7\u6dc6VEGF\/VEGFR\u5bfc\u81f4\u673a\u5236\u9610\u8ff0\u4e0d\u53ef\u4fe1\u201d\u65f6\uff0c\u5f20\u535a\u58eb\u4ef7\u503c\u767e\u4e07\u7684\u809d\u764c\u7814\u7a76\u906d\u9047\u81f4\u547d\u6253\u51fb\u2014\u2014\u8fd9\u4e0d\u4ec5\u662f\u8bed\u8a00\u95ee\u9898\uff0c\u66f4\u662f\u533b\u5b66\u6c9f\u901a\u7684\u4fe1\u4efb\u5371\u673a\u3002\u4ed6\u7684\u906d\u9047\u63ed\u793a\u4e86\u4e00\u4e2a\u6b8b\u9177\u73b0\u5b9e\uff1a\u5168\u740338%\u7684\u533b\u5b66\u7a3f\u4ef6\u56e0\u672f\u8bed\u8bef\u5dee\u88ab\u8d28\u7591\u5b66\u672f\u4e25\u8c28\u6027*\u6570\u636e\u6765\u6e90\uff1aNature Index\uff09\u3002<\/p>\n

\u533b\u5b66\u6da6\u8272\u9ad8\u6ea2\u4ef7\u80cc\u540e\u7684\u4e09\u91cd\u9632\u706b\u5899<\/strong><\/p>\n

\u4e3a\u4ec0\u4e48\u540c\u68375000\u8bcd\u8bba\u6587\uff0c\u533b\u5b66\u8bba\u6587\u6da6\u8272<\/a>\u8d39\u7528\u6bd4\u5de5\u7a0b\u5b66\u9ad850%\uff1f\u7b54\u6848\u85cf\u5728\u4e09\u4e2a\u751f\u6b7b\u6538\u5173\u7684\u7ec6\u8282\u91cc\uff1a<\/p>\n

1. \u672f\u8bed\u96f7\u533a<\/strong><\/p>\n

\u628a\u201c**cytokine**\u201d\uff08\u7ec6\u80de\u56e0\u5b50\uff09\u9519\u5199\u6210\u201c**chemokine**\u201d\uff08\u8d8b\u5316\u56e0\u5b50\uff09\uff0c\u5982\u540c\u5728\u514d\u75ab\u673a\u5236\u4e2d\u57cb\u4e0b\u903b\u8f91\u70b8\u5f39\uff1b\u5f53\u201c**STAT3\u4fe1\u53f7\u901a\u8def**\u201d\u8bef\u4f5c\u201c**STAT-3\u901a\u8def**\u201d\uff0c\u65b9\u6cd5\u8bba\u53ef\u4fe1\u5ea6\u77ac\u95f4\u5d29\u584c\u3002<\/p>\n

2. \u89c4\u8303\u6cbc\u6cfd<\/strong><\/p>\n

– ICH-GCP\u8981\u6c42\u201cP=0.049\u201d\u7edd\u4e0d\u80fd\u7b80\u5199\u4e3a\u201cP<0.05\u201d\n\n- CONSORT\u6807\u51c6\u5f3a\u5236\u4e34\u5e8a\u6570\u636e\u5448\u73b0\u7279\u5b9a\u8303\u5f0f\n \n \u4e00\u6b21\u7edf\u8ba1\u63cf\u8ff0\u5931\u8bef\u53ef\u80fd\u89e6\u53d1\u5b66\u672f\u4f26\u7406\u8c03\u67e5\n \n\n3. \u4f26\u7406\u60ac\u5d16<\/strong><\/p>\n

\u60a3\u8005\u77e5\u60c5\u540c\u610f\u4e66\u4e2d\u7684\u8868\u8ff0\u504f\u5dee\uff0c\u8db3\u4ee5\u8ba9\u7814\u7a76\u88ab\u6c38\u4e45\u5c01\u5b58\u3002\u67d0\u4e09\u7532\u533b\u9662\u7684COVID\u540e\u9057\u75c7\u7814\u7a76\u5c31\u56e0\u672a\u6807\u6ce8\u6570\u636e\u6765\u6e90\uff0c\u9677\u5165\u5b66\u672f\u4e0d\u7aef\u98ce\u6ce2\u3002
\n\"\u8bba\u6587\u6da6\u8272\n\"<\/p>\n

\u610f\u5f97\u8f91\u7684\u201c\u7cbe\u51c6\u7528\u836f\u201d\u5206\u7ea7\u65b9\u6848<\/strong><\/p>\n

\u57fa\u7840\u6025\u6551\u5305\uff080.34-0.45\u5143\/\u8bcd\uff09<\/strong><\/p>\n

\u25a0 8\u5c0f\u65f6\u6e05\u9664\u8bed\u6cd5\u611f\u67d3\uff08\u65f6\u6001\u6df7\u4e71\/\u4e3b\u8c13\u5931\u8c03\uff09<\/p>\n

\u25a0 \u7cbe\u51c6\u706d\u6d3b\u672f\u8bed\u53d8\u5f02\uff08\u5982\u89c4\u8303BRAF\u57fa\u56e0\u4e66\u5199\uff09<\/p>\n

\u25a0 \u9644\u8d6010%\u5b57\u6570\u51cf\u8d1f\u672f<\/p>\n

\u2192 \u9002\u5408\u8bed\u8a00\u5e95\u5b50\u8f83\u597d\u7684\u521d\u6295\u7a3f\u4ef6<\/p>\n

\u9ad8\u9636\u5f3a\u5316\u5242\uff080.54-0.7\u5143\/\u8bcd\uff09<\/strong><\/p>\n

75%\u533b\u5b66\u7814\u7a76\u8005\u7684\u9009\u62e9\uff0c\u56e0\u5176\u63d0\u4f9b\uff1a<\/p>\n

\u25a0 \u903b\u8f91\u795e\u7ecf\u7f51\u7edc\u91cd\u5851\u672f\uff08\u758f\u901a\u65b9\u6cd5-\u7ed3\u679c-\u7ed3\u8bba\u4f20\u5bfc\u901a\u8def\uff09<\/p>\n

\u25a0 365\u5929\u514d\u75ab\u62a4\u822a\uff08\u514d\u8d39\u5e94\u5bf9\u8fd4\u4fee\u8bed\u8a00\u653b\u51fb\uff09<\/p>\n

\u25a0 \u67e5\u91cdCT\u626b\u63cf\uff08\u62e6\u622a\u975e\u6545\u610f\u6284\u88ad\uff09<\/p>\n

\u2192 \u9ad8\u5f71\u54cd\u529b\u671f\u520a\u6295\u7a3f\u5fc5\u5907
\n
\n\u9876\u520a\u7279\u653b\u961f\uff081.39-2.12\u5143\/\u8bcd\uff09<\/strong><\/p>\n

\u25b8 \u4e09\u91cd\u4e13\u5bb6\u4f1a\u8bca\uff1a\u5b66\u79d1\u7f16\u8f91+\u9876\u520a\u5ba1\u7a3f\u4eba+\u6267\u884c\u7f16\u8f91<\/p>\n

\u25b8 \u521b\u65b0\u6027\u5b58\u6d3b\u7387\u9884\u5224\uff1a\u201c\u60a8\u7684\u7814\u7a76\u591f\u5f97\u4e0aScience\u5417\uff1f\u201d<\/p>\n

\u25b8 \u5927\u4fee\u91cd\u75c7\u76d1\u62a4\u5ba4\uff08\u56de\u590d\u4fe1\u7b56\u7565\u6307\u5bfc\uff09<\/p>\n

\u2192 \u80bf\u7624\u673a\u5236\u7b49\u70ed\u95e8\u9886\u57df\u51b2\u9876\u9009\u62e9<\/p>\n

—<\/p>\n

0.2\u5143\/\u8bcd\u7684\u201c\u751c\u871c\u9677\u9631\u201d<\/strong><\/p>\n

\u67d0\u7814\u7a76\u6240\u8d2a\u56fe\u4f4e\u4ef7\u6da6\u8272\u670d\u52a1\uff0c\u4ed8\u51fa\u60e8\u75db\u4ee3\u4ef7\uff1a<\/p>\n

– 12\u5904\u81f4\u547d\u9519\u8bef\uff08\u5982\u201cneoadjuvant\u201d\u8bef\u4f5c\u201cadjuvant\u201d\uff09<\/p>\n

– \u88ab\u300aAnnals of Surgery\u300b\u8d28\u7591\u4e13\u4e1a\u7d20\u517b<\/p>\n

– \u6210\u679c\u5ef6\u8fdf\u53d1\u88686\u4e2a\u6708\uff0c\u4e13\u5229\u4fdd\u62a4\u7a97\u5173\u95ed<\/p>\n

\u53cd\u89c2\u56db\u5ddd\u5927\u5b66\u674e\u677e\u822a\u6559\u6388\u56e2\u961f\uff1a
\n
\n\u201c\u4e13\u4e1a\u6da6\u8272\u4e0d\u662f\u4fee\u9970\u8bcd\u85fb\u7684\u5316\u5986\u5e08\uff0c\u800c\u662f\u91cd\u6784\u5b66\u672f\u53d9\u4e8b\u7684\u5efa\u7b51\u5e08\u201d<\/strong><\/p>\n

\u4e94\u5e74\u5408\u4f5c\u4e2d\uff1a<\/p>\n

\u25a0 \u8eb2\u8fc77\u6b21\u4f26\u7406\u5ba1\u67e5\u5371\u673a<\/p>\n

\u25a0 \u8bba\u6587\u88ab\u5f15\u7387\u98d9\u534740%<\/p>\n

\u25a0 \u8f6c\u6295\u671f\u520a\u8282\u77012.1\u4e07\u5143<\/p>\n

—
\n\"\u533b\u5b66\u672f\u8bed\u7684\u201c\u751f\u6b7b\u52ab\u201d\uff1a\u4e00\u7bc7\u88ab\u62d2\u7a3f\u7684\u542f\u793a\u63d2\u56fe2\"
\n47\u4e07\u7bc7\u8bba\u6587\u94f8\u9020\u7684\u4fe1\u4efb\u8d27\u5e01<\/strong><\/p>\n

\u5f53\u5df4\u897f\u764c\u75c7\u7814\u7a76\u5728\u5fb7\u56fd\u5b9e\u9a8c\u5ba4\u88ab\u5b8c\u7f8e\u590d\u73b0<\/p>\n

\u5f53\u4e2d\u56fdCOVID\u540e\u9057\u75c7\u6570\u636e\u6210\u4e3aWHO\u51b3\u7b56\u4f9d\u636e<\/p>\n

\u4e25\u8c28\u7684\u533b\u5b66\u672f\u8bed\u6b63\u5728\u6210\u4e3a\uff1a<\/p>\n

\u2705 \u8de8\u56fd\u9a8c\u8bc1\u7684\u901a\u884c\u8bc1<\/p>\n

\u2705 \u5b66\u672f\u5408\u4f5c\u7684\u786c\u901a\u8d27<\/p>\n

\u2705 \u751f\u547d\u6570\u636e\u7684\u52a0\u5bc6\u9501<\/p>\n

—<\/p>\n

\u5728\u7b97\u6cd5\u65f6\u4ee3\u5b88\u62a4\u533b\u5b66\u5723\u6bbf<\/strong><\/p>\n

\u5f53AI\u626b\u63cf\u5341\u4e07\u7bc7\u80ba\u764c\u8bba\u6587\u65f6\uff1a<\/p>\n

\u60a8\u575a\u6301\u4e66\u5199\u201c**KRAS G12D**\u201d\uff08\u800c\u975ekras g12d\uff09<\/p>\n

\u60a8\u533a\u5206\u201c**association**\u201d\u4e0e\u201c**causation**\u201d\u7684\u4e25\u8c28<\/p>\n

\u6b63\u5728\u4e3a\u672a\u6765\u533b\u5b66\u5efa\u7acb\uff1a<\/p>\n

\ud83d\udd12 \u673a\u5668\u53ef\u8bfb\u7684\u5b66\u672f\u8bda\u4fe1\u5bc6\u7801<\/p>\n

\u2695\ufe0f \u5b88\u62a4\u751f\u547d\u7684\u6700\u540e\u9632\u7ebf<\/p>\n

—<\/p>\n

\u5982\u679c\u60a8\u7684\u8bba\u6587\u6b63\u9762\u4e34\uff1a<\/strong><\/p>\n

\u26a0\ufe0f \u201c\u8bed\u8a00\u8868\u8fbe\u963b\u788d\u7406\u89e3\u201d\u7684\u6b7b\u4ea1\u5ba3\u5224<\/p>\n

\u26a0\ufe0f \u672f\u8bed\u8bef\u5dee\u5f15\u53d1\u7684\u5b66\u672f\u4fe1\u4efb\u5371\u673a<\/p>\n

\u26a0\ufe0f \u9876\u520a\u51b2\u523a\u7684\u7ec8\u6781\u8bed\u8a00\u8003\u9a8c<\/p>\n

\u610f\u5f97\u8f91\u7528\u4e09\u91cd\u76fe\u724c\u4e3a\u60a8\u62a4\u822a\uff1a<\/strong><\/p>\n

1. \u53cc\u7f16\u8f91\u5236\u6838\u9a8c<\/strong> – \u533b\u5b66\u535a\u58eb+\u671f\u520a\u4e13\u5bb6\u4ea4\u53c9\u72d9\u51fb\u672f\u8bed\u8bef\u5dee<\/p>\n

2. 365\u5929\u5168\u5468\u671f\u4fdd\u9669<\/strong> – \u62d2\u7a3f\u91cd\u6295\u96f6\u91cd\u590d\u6536\u8d39<\/p>\n

3. 8\u5c0f\u65f6\u6025\u6551\u627f\u8bfa<\/strong> – \u8d85\u65f61\u5206\u949f\u5168\u989d\u9000\u6b3e<\/p>\n

\u770b\u770b\u5176\u4ed6\u6587\u7ae0<\/strong><\/p>\n

\u82f1\u6587\u8bba\u6587\u6da6\u8272\u80fd\u5e2e\u52a9\u901a\u8fc7\u8bed\u8a00\u5ba1\u67e5\u5417\uff1f<\/a><\/p>\n

\u8bba\u6587\u6da6\u8272\u79d8\u7c4d\uff1a\u4ece\u8bed\u8a00\u7ec6\u8282\u5230\u7ed3\u6784\u4f18\u5316\u7684\u5168\u9762\u63d0\u5347<\/a><\/p>\n

\u82f1\u6587\u8bba\u6587\u6da6\u8272\u540e\u8fd8\u9700\u8981\u4eba\u5de5\u4fee\u6539\u5417\uff1f<\/a><\/p>\n

\"\u533b\u5b66\u672f\u8bed\u7684\u201c\u751f\u6b7b\u52ab\u201d\uff1a\u4e00\u7bc7\u88ab\u62d2\u7a3f\u7684\u542f\u793a\u63d2\u56fe3\"<\/p>\n","protected":false},"excerpt":{"rendered":"

\u5f53\u300a\u67f3\u53f6\u5200\u300b\u5ba1\u7a3f\u610f\u89c1\u6307\u51fa\u201c\u6df7\u6dc6VEGF\/VEGFR\u5bfc\u81f4\u673a\u5236\u9610\u8ff0\u4e0d\u53ef\u4fe1\u201d\u65f6\uff0c\u5f20\u535a\u58eb\u4ef7\u503c\u767e\u4e07\u7684\u809d\u764c\u7814\u7a76\u906d\u9047\u81f4\u547d\u6253\u51fb […]<\/p>\n","protected":false},"author":2,"featured_media":3094,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1],"tags":[50],"class_list":["post-5965","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-editing","tag-50"],"_links":{"self":[{"href":"https:\/\/www.editage.cn\/sci-writing\/wp-json\/wp\/v2\/posts\/5965","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.editage.cn\/sci-writing\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.editage.cn\/sci-writing\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.editage.cn\/sci-writing\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.editage.cn\/sci-writing\/wp-json\/wp\/v2\/comments?post=5965"}],"version-history":[{"count":3,"href":"https:\/\/www.editage.cn\/sci-writing\/wp-json\/wp\/v2\/posts\/5965\/revisions"}],"predecessor-version":[{"id":6074,"href":"https:\/\/www.editage.cn\/sci-writing\/wp-json\/wp\/v2\/posts\/5965\/revisions\/6074"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.editage.cn\/sci-writing\/wp-json\/wp\/v2\/media\/3094"}],"wp:attachment":[{"href":"https:\/\/www.editage.cn\/sci-writing\/wp-json\/wp\/v2\/media?parent=5965"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.editage.cn\/sci-writing\/wp-json\/wp\/v2\/categories?post=5965"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.editage.cn\/sci-writing\/wp-json\/wp\/v2\/tags?post=5965"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}