{"id":40440,"date":"2014-03-18T06:32:07","date_gmt":"2014-03-18T01:02:07","guid":{"rendered":"https:\/\/new.editage.cn\/insights\/research\/cause-of-fragile-x-sysndrome-uncovered"},"modified":"2026-01-08T11:15:50","modified_gmt":"2026-01-08T05:45:50","slug":"cause-of-fragile-x-sysndrome-uncovered-4755","status":"publish","type":"research","link":"https:\/\/www.editage.cn\/insights\/cause-of-fragile-x-sysndrome-uncovered-4755\/","title":{"rendered":"Cause of fragile X sysndrome uncovered"},"content":{"rendered":"<p style=\"text-align: justify;\"><span style=\"font-family:verdana,geneva,sans-serif;\"><span style=\"font-size:14px;\">A new study has found that fragile X syndrome, the most common genetic cause of mental retardation and autism, occurs because of a mechanism that shuts off the gene associated with the disease. While researchers have known that the excess repetition of a particular segment of the genetic code is the reason behind the disease, they were unsure why a large number of these repetitions sets the disease process in motion. Using stem cells from donated human embryos that tested positive for fragile X syndrome, the study\u2019s researchers found that early on in fetal development, messenger RNA begins sticking itself onto the DNA of the fragile X syndrome gene, thus making it inactive and unable to produce a protein crucial to the transmission of signals between brain cells. Read more in <a href=\"https:\/\/www.sciencedaily.com\/releases\/2014\/02\/140227142605.htm\" rel=\"nofollow\" target=\"_blank\"><em>Science<\/em><\/a>.<\/span><\/span><\/p>\n<p style=\"text-align: justify;\">\u00a0<\/p>\n<p style=\"text-align: justify;\"><span style=\"font-family:verdana,geneva,sans-serif;\"><span style=\"font-size:14px;\">D Colak et al., <em>Science<\/em>, 2014. DOI: 10.1126\/science.1245831<\/span><\/span><\/p>\n","protected":false},"author":27,"featured_media":60567,"template":"","meta":{"_acf_changed":false,"inline_featured_image":false},"new_tags":[356],"series":[],"subject":[358],"class_list":["post-40440","research","type-research","status-publish","has-post-thumbnail","hentry","new_tags-356","subject-358"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Cause of fragile X sysndrome uncovered | Editage Insights<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"http:\/\/localhost\/editagechinanew\/cause-of-fragile-x-sysndrome-uncovered-4755\" \/>\n<meta property=\"og:locale\" content=\"zh_CN\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Cause of fragile X sysndrome uncovered | Editage 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