{"id":39731,"date":"2017-02-13T09:18:45","date_gmt":"2017-02-13T03:48:45","guid":{"rendered":"https:\/\/new.editage.cn\/insights\/%e7%be%8e%e5%9b%bd%e5%8f%af%e9%87%8d%e5%a4%8d%e6%80%a7%e9%a1%b9%e7%9b%ae-reproducibility-project-%e9%a6%96%e6%ac%a1%e8%b0%83%e6%9f%a5%e5%8f%91%e7%8e%b0%e7%82%b9%e5%87%ba%e5%8f%af%e9%87%8d%e5%a4%8d"},"modified":"2026-01-07T16:23:50","modified_gmt":"2026-01-07T10:53:50","slug":"mei-guo-ke-chong-fu-xing-xiang-mu-reproducibility-project-shou-ci-diao-cha-fa-xian-dian-chu-ke-chong-fu-wei-ji-2709","status":"publish","type":"post","link":"https:\/\/www.editage.cn\/insights\/mei-guo-ke-chong-fu-xing-xiang-mu-reproducibility-project-shou-ci-diao-cha-fa-xian-dian-chu-ke-chong-fu-wei-ji-2709\/","title":{"rendered":"\u7f8e\u56fd\u53ef\u91cd\u590d\u6027\u9879\u76ee (Reproducibility Project) \u9996\u6b21\u8c03\u67e5\u53d1\u73b0\u70b9\u51fa\u53ef\u91cd\u590d\u5371\u673a"},"content":{"rendered":"<p>\u7f8e\u56fd\u53ef\u91cd\u590d\u6027\u9879\u76ee <a href=\"https:\/\/osf.io\/e81xl\/wiki\/home\/\" rel=\"nofollow\" target=\"_blank\">Reproducibility Project: Cancer Biology<\/a> \u53d1\u5e03\u4e86\u4ed6\u4eec\u6700\u5148\u5c1d\u8bd5\u91cd\u590d\u7684\u4e94\u4e2a\u7814\u7a76\u7684\u7ed3\u679c\u62a5\u544a\uff0c\u62a5\u544a\u7ed3\u679c\u5728\u751f\u7269\u5b66\u754c\u9020\u6210\u4e00\u80a1\u66b4\u98ce\u3002\u6b64\u6b21\u53d1\u73b0\u53d1\u8868\u5728\u300a<a href=\"https:\/\/elifesciences.org\/content\/6\/e23383\" rel=\"nofollow\" target=\"_blank\">eLife<\/a>\u300b\u671f\u520a\u4e0a\uff0c\u5185\u5bb9\u63d0\u5230\u5728\u8fd9\u4e94\u4e2a\u7814\u7a76\u4e2d\uff0c\u53ea\u6709\u4e24\u4e2a\u80fd\u6210\u529f\u91cd\u590d\uff0c\u4e00\u4e2a\u5931\u8d25\uff0c\u800c\u5269\u4e0b\u7684\u4e24\u4e2a\u662f\u201c\u65e0\u6cd5\u9610\u91ca\u7684\u7ed3\u679c (<span style=\"background-color: rgb(255, 255, 255); color: rgb(51, 51, 51); font-family: &quot;Helvetica Neue&quot;, Helvetica, Arial, sans-serif; font-size: 14px; text-align: justify;\">uninterpretable results)<\/span>\u201d\u3002<\/p>\n<p>\u53ef\u91cd\u590d\u9879\u76ee\u5e76\u4e0d\u662f\u7b2c\u4e00\u4e2a\u60f3\u8981\u91cd\u590d\u53d1\u8868\u7ed3\u679c\u7684\u9879\u76ee\u3002\u5728 2012 \u5e74\uff0c\u751f\u7269\u79d1\u6280\u516c\u53f8 Amgen \u5c31\u53d1\u8868\u8fc7\u4e00\u4efd\u62a5\u544a\uff0c\u6307\u51fa\u516c\u53f8\u7684\u7814\u7a76\u4eba\u5458<a href=\"https:\/\/www.reuters.com\/article\/us-science-cancer-idUSBRE82R12P20120328\" rel=\"nofollow\" target=\"_blank\">\u65e0\u6cd5\u91cd\u73b0 53 \u4e2a\u7a81\u7834\u6027\u764c\u75c7\u7814\u7a76\u4e2d\u7684 47 \u4e2a\u7ed3\u679c<\/a>\u3002\u53d7\u8be5\u884c\u52a8\u542f\u53d1\uff0c<a href=\"https:\/\/www.scienceexchange.com\/\" rel=\"nofollow\" target=\"_blank\">Science Exchange<\/a> \u548c<a href=\"https:\/\/cos.io\/\" rel=\"nofollow\" target=\"_blank\">\u5f00\u653e\u79d1\u5b66\u4e2d\u5fc3<\/a> (Center for Open Science) \u8054\u624b\u5408\u4f5c\u63a8\u51fa\u53ef\u91cd\u590d\u9879\u76ee\uff0c\u590d\u5236 29 \u4e2a\u5728 2010 \u5e74\u81f3 2012 \u5e74\u95f4\u5728\u4e34\u5e8a\u524d\u9636\u6bb5\u53d1\u8868\u7684\u91cd\u8981\u764c\u75c7\u7814\u7a76\u3002\u4e0e Amgen \u7684\u9879\u76ee\u4e0d\u540c\u7684\u662f\uff0c\u53ef\u91cd\u590d\u9879\u76ee\u7684\u8fc7\u7a0b\u548c\u53d1\u73b0\u90fd\u4f1a\u514d\u8d39\u5f00\u653e\u3002<\/p>\n<p>\u4ee5\u4e0b\u662f\u53ef\u91cd\u590d\u9879\u76ee\u7684\u91cd\u590d\u7814\u7a76\u7ec6\u8282\uff1a<\/p>\n<ul>\n<li>\u5728\u4e94\u4e2a\u7814\u7a76\u4e2d\uff0c\u6210\u529f\u91cd\u590d\u7684\u4e24\u4e2a\u7814\u7a76\u4e3a\uff1a\u65af\u5766\u798f\u5927\u5b66\u8ba1\u7b97\u751f\u7269\u5b66\u5bb6 Atul Butte \u9886\u5bfc\u7684 <a href=\"https:\/\/stm.sciencemag.org\/content\/3\/96\/96ra77\" rel=\"nofollow\" target=\"_blank\">Discovery and preclinical validation of drug indications using compendia of public gene expression data<\/a> \u4ee5\u53caConstantine Mitsiades \u5728\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662(Dana-Farber Cancer Institute) \u671f\u95f4\u5e26\u9886\u7684 <a href=\"https:\/\/www.cell.com\/cell\/abstract\/S0092-8674(11)00943-3?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867411009433%3Fshowall%3Dtrue\" rel=\"nofollow\" target=\"_blank\">BET Bromodomain inhibition as\u00a0a therapeutic strategy to target c-Myc<\/a>\u3002<\/li>\n<li>\u65e0\u6cd5\u9610\u91ca\u7684\u7814\u7a76\u4e3a\u4e39\u5a1c\u6cd5\u4f2f\u764c\u75c7\u7814\u7a76\u9662 Petar Stojanov \u9886\u519b\u7684 <a href=\"https:\/\/www.nature.com\/nature\/journal\/v485\/n7399\/full\/nature11071.html\" rel=\"nofollow\" target=\"_blank\">Melanoma genome sequencing reveals frequent\u00a0<em>PREX2<\/em>\u00a0mutations<\/a> \u548c\u65af\u5766\u798f\u5e72\u7ec6\u80de\u751f\u7269\u5b66\u5bb6 Irving Weissman \u7684 <a href=\"https:\/\/www.pnas.org\/content\/109\/17\/6662\" rel=\"nofollow\" target=\"_blank\">The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors<\/a>\u3002<\/li>\n<li>\u552f\u4e00\u65e0\u6cd5\u91cd\u590d\u7684\u7814\u7a76\u662f\u52a0\u5229\u798f\u5c3c\u4e9a\u6851\u798f\u5fb7-\u4f2f\u7eb3\u59c6-\u666e\u5229\u8d1d\u65af\u533b\u5b66\u63a2\u7d22\u7814\u7a76\u6240 (Sanford Burnham Prebys Medical Discovery Institute, SBP) \u764c\u75c7\u751f\u7269\u5b66\u5bb6 Erkki Ruoslahti \u4e3b\u5bfc\u7684 <a href=\"https:\/\/science.sciencemag.org\/content\/328\/5981\/1031\" rel=\"nofollow\" target=\"_blank\">Coadministration of a tumor-penetrating peptide enhances the efficacy of cancer drugs<\/a>\u3002<\/li>\n<\/ul>\n<p>\u8bb8\u591a\u79d1\u7814\u4eba\u5458\uff0c\u7279\u522b\u662f\u751f\u7269\u5b66\u5bb6\uff0c\u5bf9\u8fd9\u4e2a\u9879\u76ee\u8868\u793a\u652f\u6301\uff0c\u56e0\u4e3a\u9879\u76ee\u66dd\u5149\u4e86\u53d1\u8868\u6587\u732e\u7f3a\u5c11\u7684\u7814\u7a76\u65b9\u6cd5\u7ec6\u8282\uff0c\u9f13\u52b1\u79d1\u7814\u4eba\u5458\u4e0d\u8981\u8f7b\u4fe1\u8868\u9762\u4e0a\u7684\u7ed3\u679c\u3002<\/p>\n<p>\u4e0d\u8fc7\uff0c\u4e5f\u6709\u4eba\u6307\u51fa\u91cd\u590d\u751f\u7269\u7814\u7a76\u662f\u975e\u5e38\u56f0\u96be\u7684\uff0c\u56e0\u4e3a\u5176\u4e2d\u7275\u6d89\u7684\u590d\u6742\u7a0b\u5ea6\u6709\u597d\u51e0\u5c42\uff0c\u56e0\u6b64\u4ed6\u4eec\u5efa\u8bae\u4e0d\u8981\u5c06\u65e0\u6cd5\u590d\u5236\u7684\u7814\u7a76\u5f53\u6210\u6700\u7ec8\u88c1\u51b3\u3002\u52a0\u5229\u798f\u5c3c\u4e9a Palo Alto \u65af\u5766\u798f\u5927\u5b66\u7684\u6d41\u884c\u75c5\u5b66\u5bb6 John Ioannidis \u603b\u7ed3\u4e86\u8fd9\u4e2a\u9879\u76ee\u53d1\u73b0\uff1a\u300c\u7efc\u5408\u6765\u770b\uff0c\u662f\u6709\u91cd\u590d\u95ee\u9898\u3002\u300d<\/p>\n<p>\u00a0<\/p>\n<p><strong>\u53c2\u8003\u8d44\u6599<\/strong><\/p>\n<ul>\n<li style=\"text-align: justify;\"><a href=\"https:\/\/www.sciencemag.org\/news\/2017\/01\/rigorous-replication-effort-succeeds-just-two-five-cancer-papers\" rel=\"nofollow\" target=\"_blank\">Rigorous replication effort succeeds for just two of five cancer papers<\/a><\/li>\n<li style=\"text-align: justify;\"><a href=\"https:\/\/www.nature.com\/news\/cancer-reproducibility-project-releases-first-results-1.21304\" rel=\"nofollow\" target=\"_blank\">Cancer reproducibility project releases first results<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u7f8e\u56fd\u53ef\u91cd\u590d\u6027\u9879\u76ee Reproducibility Project: Cancer Biology \u53d1\u5e03\u4e86\u4ed6\u4eec\u6700 [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":60567,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[565,528,55],"tags":[143,13],"new_categories":[],"new_tags":[],"series":[],"class_list":["post-39731","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-zai-xian-xing-130","category-ke-yan-fa-biao-xin-xiao-xi-155","category-hang-ye-xin-wen-31","tag-zai-xian-xing-130","tag-ke-yan-fa-biao-xin-xiao-xi-155"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>\u7f8e\u56fd\u53ef\u91cd\u590d\u6027\u9879\u76ee (Reproducibility Project) \u9996\u6b21\u8c03\u67e5\u53d1\u73b0\u70b9\u51fa\u53ef\u91cd\u590d\u5371\u673a | \u610f\u5f97\u8f91\u4e13\u5bb6\u89c6\u70b9 Editage Insights<\/title>\n<meta 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