{"id":39024,"date":"2018-10-09T04:41:46","date_gmt":"2018-10-08T23:11:46","guid":{"rendered":"https:\/\/new.editage.cn\/insights\/2018-%e8%af%ba%e8%b4%9d%e5%b0%94%e7%94%9f%e7%90%86%e5%ad%a6%e6%88%96%e5%8c%bb%e5%ad%a6%e5%a5%96%e9%a2%81%e5%8f%91%e7%bb%99%e6%89%be%e5%88%b0%e7%99%8c%e7%97%87%e6%96%b0%e6%96%b9%e6%b2%bb%e7%96%97"},"modified":"2026-01-07T16:22:10","modified_gmt":"2026-01-07T10:52:10","slug":"2018-nuo-bei-er-sheng-li-xue-huo-yi-xue-jiang-ban-fa-gei-zhao-dao-ai-zheng-xin-fang-zhi-liao-shi-de-yan-jiu-yu-1933","status":"publish","type":"post","link":"https:\/\/www.editage.cn\/insights\/2018-nuo-bei-er-sheng-li-xue-huo-yi-xue-jiang-ban-fa-gei-zhao-dao-ai-zheng-xin-fang-zhi-liao-shi-de-yan-jiu-yu-1933\/","title":{"rendered":"2018 \u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u9881\u53d1\u7ed9\u627e\u5230\u764c\u75c7\u65b0\u65b9\u6cbb\u7597\u5f0f\u7684\u7814\u7a76\u5458"},"content":{"rendered":"<p style=\"text-align:justify; margin:0in 0in 10pt\"><span style=\"font-size:11pt\"><span style=\"line-height:115%\"><span style=\"font-family:Calibri,sans-serif\"><span lang=\"ZH-CN\" style=\"font-family:SimSun\" xml:lang=\"ZH-CN\">\u5361\u7f57\u7433\u65af\u5361\u5b66\u9662\u7684\u8bfa\u8d1d\u5c14\u5927\u4f1a<\/span><a href=\"https:\/\/www.nobelprize.org\/prizes\/medicine\/\" rel=\"nofollow\" style=\"color:blue; text-decoration:underline\" target=\"_blank\"><span lang=\"ZH-CN\" style=\"font-family:SimSun\" xml:lang=\"ZH-CN\">\u5ba3\u5e03<\/span><\/a><span lang=\"ZH-CN\" style=\"font-family:SimSun\" xml:lang=\"ZH-CN\">\u4eca\u5e74\u7684\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u5f97\u4e3b\uff0c\u7531\u7f8e\u56fd\u5fb7\u514b\u8428\u65af\u5927\u5b66\u7684<\/span> James Allison <span lang=\"ZH-CN\" style=\"font-family:SimSun\" xml:lang=\"ZH-CN\">\u548c\u65e5\u672c\u4eac\u90fd\u5927\u5b66\u7684\u672c\u5eb6\u4f51<\/span> (Tasuku Honjo) <span lang=\"ZH-CN\" style=\"font-family:SimSun\" xml:lang=\"ZH-CN\">\u5171\u540c\u83b7\u5956\uff0c\u5f97\u5956\u539f\u56e0\u4e3a\u5efa\u7acb\u201c<\/span><a href=\"https:\/\/www.nytimes.com\/2018\/10\/01\/health\/nobel-prize-medicine.html\" rel=\"nofollow\" style=\"color:blue; text-decoration:underline\" target=\"_blank\"><span lang=\"ZH-CN\" style=\"font-family:SimSun\" xml:lang=\"ZH-CN\">\u5d2d\u65b0\u7684\u764c\u75c7\u6cbb\u7597\u539f\u7406<\/span><\/a><span lang=\"ZH-CN\" style=\"font-family:SimSun\" xml:lang=\"ZH-CN\">\u201d\uff0c\u4e24\u4f4d\u5f97\u5956\u4eba\u4e3a\u53d1\u5c55\u5f00\u62d3\u6027\u7684\u6cbb\u7597\u65b9\u6cd5\u94fa\u5e73\u4e86\u9053\u8def\uff0c\u85c9\u7531\u4eba\u4f53\u514d\u75ab\u7cfb\u7edf\u653b\u51fb\u5bf9\u6297\u764c\u7ec6\u80de\u3002<\/span><\/span><\/span><\/span><\/p>\n<p style=\"text-align:justify; margin:0in 0in 10pt\"><span style=\"font-size:11pt\"><span style=\"line-height:115%\"><span style=\"font-family:Calibri,sans-serif\"><span lang=\"ZH-CN\" style=\"font-family:SimSun\" xml:lang=\"ZH-CN\">\u764c\u75c7\u662f\u5de8\u5927\u7684\u5065\u5eb7\u6740\u624b\uff0c\u4f20\u7edf\u7684\u764c\u75c7\u6cbb\u7597\u65b9\u6cd5\u4e3b\u8981\u662f\u624b\u672f\u548c\u653e\u5c04\u6cbb\u7597\uff0c\u4f46\u672c\u5eb6\u4f51\u548c<\/span> Allison <span lang=\"ZH-CN\" style=\"font-family:SimSun\" xml:lang=\"ZH-CN\">\u5404\u81ea\u7684\u5de5\u4f5c\u5c06\u201c\u4eba\u4eec\u6000\u7591\u4e86\u6570\u5341\u5e74\u7684\u514d\u75ab\u7597\u6cd5\u53d8\u4e3a\u53ef\u80fd\u201d\uff0c\u7eaa\u5ff5\u65af\u9686<\/span>&#8211;<span lang=\"ZH-CN\" style=\"font-family:SimSun\" xml:lang=\"ZH-CN\">\u51ef\u7279\u7433\u764c\u75c7\u4e2d\u5fc3\u764c\u75c7\u4e13\u5bb6<\/span> Jedd Wolchok <span lang=\"ZH-CN\" style=\"font-family:SimSun\" xml:lang=\"ZH-CN\">\u535a\u58eb\u5982\u6b64\u8bf4\u9053\u3002<\/span><\/span><\/span><\/span><\/p>\n<p style=\"text-align:justify; margin:0in 0in 10pt\"><span style=\"font-size:11pt\"><span style=\"line-height:115%\"><span style=\"font-family:Calibri,sans-serif\"><span lang=\"ZH-CN\" style=\"font-family:SimSun\" xml:lang=\"ZH-CN\">\u4e24\u4f4d\u7814\u7a76\u4eba\u5458\u5f00\u53d1\u7684\u65b9\u6cd5\u79f0\u4f5c\u201c\u514d\u75ab\u68c0\u67e5\u70b9\u963b\u65ad<\/span> (immune checkpoint therapy)<span lang=\"ZH-CN\" style=\"font-family:SimSun\" xml:lang=\"ZH-CN\">\u201d\uff0c\u8fd9\u4e2a\u65b9\u6cd5\u66f4\u5e26\u6765\u4e86\u65b0\u578b\u836f\u7269\u5f00\u53d1\uff0c\u5e76\u5728\u591a\u4f4d\u75c5\u60a3\u8eab\u4e0a\u8bc1\u660e\u6709\u6548\u3002<\/span>Allison <span lang=\"ZH-CN\" style=\"font-family:SimSun\" xml:lang=\"ZH-CN\">\u7814\u7a76<\/span> CTLA-4 <span lang=\"ZH-CN\" style=\"font-family:SimSun\" xml:lang=\"ZH-CN\">\u86cb\u767d\uff0c\u627e\u51fa\u7528\u514d\u75ab\u7cfb\u7edf\u5bf9\u6297\u764c\u7ec6\u80de\u7684\u65b9\u6cd5\uff0c\u800c\u4e0d\u662f\u6cbb\u7597\u764c\u7ec6\u80de\u672c\u8eab\u3002\u53e6\u4e00\u65b9\u9762\uff0c\u672c\u5eb6\u4f51\u53d1\u73b0\u53e6\u5916\u4e00\u79cd\u53eb<\/span> PD-1 <span lang=\"ZH-CN\" style=\"font-family:SimSun\" xml:lang=\"ZH-CN\">\u7684\u86cb\u767d\uff0c\u80fd\u5e2e\u52a9\u514d\u75ab\u7cfb\u7edf\u5bf9\u6297\u764c\u7ec6\u80de\u3002<\/span><\/span><\/span><\/span><\/p>\n<p style=\"margin:0in 0in 10pt\"><span style=\"font-size:11pt\"><span style=\"line-height:115%\"><span style=\"font-family:Calibri,sans-serif\"><span lang=\"ZH-CN\" style=\"font-family:SimSun\" xml:lang=\"ZH-CN\">\u5728<\/span> Allison <span lang=\"ZH-CN\" style=\"font-family:SimSun\" xml:lang=\"ZH-CN\">\u6240\u5c5e\u5355\u4f4d\u6240\u53d1\u8868\u7684\u58f0\u660e\u4e2d\uff0c\u4ed6\u8868\u793a\uff1a\u201c\u6211\u5f88\u8363\u5e78\u80fd\u83b7\u6b64\u6b8a\u8363\u3002\u201d<\/span><\/span><\/span><\/span><\/p>\n<p style=\"margin:0in 0in 10pt\"><span style=\"font-size:11pt\"><span style=\"line-height:115%\"><span style=\"font-family:Calibri,sans-serif\"><span lang=\"ZH-CN\" style=\"font-family:SimSun\" xml:lang=\"ZH-CN\">\u610f\u5f97\u8f91\u4e13\u5bb6\u89c6\u70b9\u606d\u559c\u6240\u6709\u5f97\u5956\u4eba\u5458\uff01<\/span><\/span><\/span><\/span><\/p>\n<p style=\"margin:0in 0in 10pt\"><span style=\"font-size:11pt\"><span style=\"line-height:115%\"><span style=\"font-family:Calibri,sans-serif\"><b><span lang=\"ZH-CN\" style=\"font-family:SimSun\" xml:lang=\"ZH-CN\">\u610f\u5f97\u8f91\u4e13\u5bb6\u89c6\u70b9\u76f8\u5173\u63a8\u8350\u9605\u8bfb\uff1a<\/span><\/b><\/span><\/span><\/span><\/p>\n<ul>\n<li style=\"margin: 0in 0in 10pt;\"><span style=\"font-size:11pt\"><span style=\"line-height:115%\"><span style=\"font-family:Calibri,sans-serif\"><a href=\"https:\/\/www.editage.cn\/insights\/2579.html\" style=\"color:blue; text-decoration:underline\" target=\"_blank\"><span lang=\"ZH-CN\" style=\"font-family:SimSun\" xml:lang=\"ZH-CN\">\u4e09\u4f4d\u79d1\u5b66\u5bb6\u56e0\u5f7b\u5e95\u6539\u53d8\u6fc0\u5149\u7269\u7406\u5b66\u83b7\u5f97<\/span> 2018 <span lang=\"ZH-CN\" style=\"font-family:SimSun\" xml:lang=\"ZH-CN\">\u8bfa\u8d1d\u5c14\u7269\u7406\u5b66\u5956<\/span><\/a><\/span><\/span><\/span><\/li>\n<li style=\"margin: 0in 0in 10pt;\"><span style=\"font-size:11pt\"><span style=\"line-height:115%\"><span style=\"font-family:Calibri,sans-serif\"><a href=\"https:\/\/www.editage.cn\/insights\/2578.html\" style=\"color:blue; text-decoration:underline\" target=\"_blank\">2018 <span lang=\"ZH-CN\" style=\"font-family:SimSun\" xml:lang=\"ZH-CN\">\u8bfa\u8d1d\u5c14\u5316\u5b66\u5956\u5f97\u4e3b\u7528\u5b9a\u5411\u8fdb\u5316\u9020\u5c31\u65b0\u836f\u7269<\/span><\/a><\/span><\/span><\/span><\/li>\n<li style=\"margin: 0in 0in 10pt;\"><span style=\"font-size:11pt\"><span style=\"line-height:115%\"><span style=\"font-family:Calibri,sans-serif\"><a href=\"https:\/\/www.editage.cn\/insights\/2247.html\" style=\"color:blue; text-decoration:underline\" target=\"_blank\">2017 <span lang=\"ZH-CN\" style=\"font-family:SimSun\" xml:lang=\"ZH-CN\">\u8bfa\u8d1d\u5c14\u533b\u5b66\u5956\u9881\u53d1\u7ed9\u663c\u591c\u8282\u5f8b\u7814\u7a76<\/span><\/a><\/span><\/span><\/span><\/li>\n<\/ul>\n<p style=\"margin:0in 0in 10pt\"><span style=\"font-size:11pt\"><span style=\"line-height:115%\"><span style=\"font-family:Calibri,sans-serif\"><b><span lang=\"ZH-CN\" style=\"font-family:SimSun\" xml:lang=\"ZH-CN\">\u53c2\u8003\u8d44\u6599\uff1a<\/span><\/b><\/span><\/span><\/span><\/p>\n<ul>\n<li style=\"margin: 0in 0in 10pt;\"><span style=\"font-size:11pt\"><span style=\"line-height:115%\"><span style=\"font-family:Calibri,sans-serif\"><a href=\"https:\/\/www.nytimes.com\/2018\/10\/01\/health\/nobel-prize-medicine.html\" rel=\"nofollow\" style=\"color:blue; text-decoration:underline\" target=\"_blank\">2018 Nobel Prize in Medicine Awarded to 2 Cancer Immunotherapy Researchers<\/a><\/span><\/span><\/span><\/li>\n<li style=\"margin: 0in 0in 10pt;\"><span style=\"font-size:11pt\"><span style=\"line-height:115%\"><span style=\"font-family:Calibri,sans-serif\"><a href=\"https:\/\/www.indiatoday.in\/education-today\/gk-current-affairs\/story\/winners-of-2018-nobel-medicine-prize-cancer-immunotherapy-1354614-2018-10-03\" rel=\"nofollow\" style=\"color:blue; text-decoration:underline\" target=\"_blank\">2018 Nobel Prize in Medicine goes to immunologists James Allison and Tasuku Honjo who revolutionised cancer immunotherapy<\/a><\/span><\/span><\/span><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>\u5361\u7f57\u7433\u65af\u5361\u5b66\u9662\u7684\u8bfa\u8d1d\u5c14\u5927\u4f1a\u5ba3\u5e03\u4eca\u5e74\u7684\u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u5f97\u4e3b\uff0c\u7531\u7f8e\u56fd\u5fb7\u514b\u8428\u65af\u5927\u5b66\u7684 James Allison [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":60567,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"footnotes":""},"categories":[559,55,605],"tags":[164,182],"new_categories":[],"new_tags":[],"series":[],"class_list":["post-39024","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-ke-xue-jie-jiang-xiang-252","category-hang-ye-xin-wen-31","category-nuo-bei-er-jiang-yu-huo-jiang-ren-258","tag-ke-xue-jie-jiang-xiang-252","tag-nuo-bei-er-jiang-yu-huo-jiang-ren-258"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.5 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>2018 \u8bfa\u8d1d\u5c14\u751f\u7406\u5b66\u6216\u533b\u5b66\u5956\u9881\u53d1\u7ed9\u627e\u5230\u764c\u75c7\u65b0\u65b9\u6cbb\u7597\u5f0f\u7684\u7814\u7a76\u5458 | Editage Insights<\/title>\n<meta name=\"robots\" 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