You are here

Researchers discover a way of controlling stem cell growth using beams of light

意得辑专家视点 | 2015年8月28日 | 1,361 浏览次数
Researchers discover that stem cell growth can be controlled using beams of light

Stem cells receive various molecular cues, but they differentiate between these cues i.e. they ignore the irrelevant cues and respond only to the crucial signs by rapidly developing to form major organ systems of the body. To understand how stem cells are able to do this, researchers at University of California, San Francisco (UCSF) studied engineered cultured mouse embryonic stem cells. Using a pulse of blue light, they controlled the Brn2 gene, a potent neural differentiation cue, to observe the stem cells’ response to this gene. Only if the Brn2 signal is strong enough and is maintained for an appropriate time, the cells respond by transforming into neurons. In addition, the researchers used the CRISPR-Cas9 gene editing system and found that the transcription factor Nanog plays a key role in helping the cells distinguish between noise and actual developmental cues. When the Brn2 signal is on, it disrupts a molecular feedback loop that keeps the cell stable. As a result, Nanog protein levels start dropping but it takes four hours to dissipate completely, after which the cells rapidly convert into neurons. If the signal turns out to be a fluke, Nano levels rebound, alerting the cells of a fluke signal. The research team sees this study to be the foundation for further research on growing new organs from stem cells.

Read more in Science Daily

重新发布

喜欢这篇文章的内容吗?欢迎重复发表!
《意得辑专家视点》深信知识需要开放给所有大众并传播,因此我们鼓励读者重复发表我们的内容,重复发表形式可为在线或印刷。我们采用知识共享(Creative Commons license),只要您遵守以下事项,即可免费重复发表我们的内容:
  • 作者信息:请尊重我们的作者,他们花费了时间精力为您撰写这些有价值的内容,重复发表时加注作者信息。
  • 意得辑专家视点:必须注明文章出自《意得辑专家视点》。
  • 表达您的情意:您可以加句“前往《意得辑专家视点》阅读全文”之类的话,啊,还有,别忘了加上文章链接。
  • 重复使用图片:要使用某些文章的图片必须事先取得许可,并加注图片原始出处。
  • 镶嵌代码:要重复使用这篇文章最简单的方式就是将下面的代码复制贴上您的页面!

 

请将上方代码直接复制贴上到您的网站,即可重新发布